Kisspeptin

Kisspeptin has recently emerged as a key regulator of the mammalian reproductive axis.

It is known that kisspeptin, acting centrally via the kisspeptin receptor, stimulates secretion of gonadotrophin releasing hormone (GnRH).

Loss of kisspeptin signalling causes hypogonadotropic hypogonadism in humans and other mammals.

Kisspeptin interacts with other neuropeptides such as neurokinin B and dynorphin, to regulate GnRH pulse generation.

In addition, a growing body of evidence suggests that kisspeptin signalling is regulated by nutritional status and stress levels (cortisol related).

Kisspeptin may also represent a novel potential therapeutic target in the treatment of fertility disorders.

Early human studies suggest that peripheral exogenous kisspeptin administration stimulates gonadotrophin release in healthy adults and in patients with certain forms of infertility.

• Plays a critical role in the onset of puberty
• Regulates seasonal reproduction
• Regulates gonadal steroidal feedback to hypothalamus
• Has direct gonadal effects
• Can stimulate secretion of aldosterone and the release of insulin.
• Has effects on the limbic system

• Primary hypogonadism
• Endogenous testosterone support
• Fertility support
• Improving ovulation and egg implantation
• Preventing ectopic pregnancy
• Physiologic hormone replacement therapy (HRT)
• Physiologic gonadotropin hormone release
• Diabetes/insulin resistance support
• Potential adjunct of metastatic prevention in cancer
• Potential support for mood disorders

• SQ (100 mcg) daily at bedtime.

• Kisspeptin peptide is reported safe in recommended dosages As with all injections, redness and pain at the site of injection may be present
• Rare adverse reactions include erythema, transient muscle atrophy, polyarthralgia combined with hand edema, and rash.